In response to the rapid advancements in artificial intelligence (AI) and the evolving landscape of patent law, the United States Patent and Trademark Office (USPTO) has issued a comprehensive guidance update on patent subject matter eligibility, particularly focusing on AI inventions. This update, aligned with Executive Order 14110 on the “Safe, Secure, and Trustworthy Development and Use of Artificial Intelligence,” aims to provide clarity and consistency in evaluating the subject matter eligibility of AI-related patent claims.